Bieber T, Braun-Falco O
Department of Dermatology, Ludwig-Maximilians University, Munich, West Germany.
Acta Derm Venereol. 1989;69(2):175-8.
Normal skin and psoriatic lesions from 35 patients were investigated immunohistochemically with regard to the CD1a+ cell population (Langerhans' cells and indeterminate cells) in the epidermis as well as in the dermal infiltrate. In the normal-appearing skin, we found the regularly typical pattern of CD1a+ dendritic cells in suprabasal position, but in lesional skin of chronic psoriasis the CD1a+ cells were scattered in the acanthotic epidermis. In initial lesions, CD1a+ cells represent up to 50-60% of the infiltrating cells of the dermal compartment, in several cases being preferentially localized in the upper part of the papillar dermis close up to the epidermal CD1a+ cells in basal position, whereas in chronic psoriasis they represent less than 10%. These results suggest that in psoriasis vulgaris, CD1a+ cells actively migrate between the epidermis and the dermal vessels.
对35例患者的正常皮肤和银屑病皮损进行了免疫组织化学研究，观察表皮以及真皮浸润中CD1a+细胞群（朗格汉斯细胞和不确定细胞）的情况。在外观正常的皮肤中，我们发现CD1a+树突状细胞在基底上层呈规则的典型分布模式，但在慢性银屑病的皮损中，CD1a+细胞散在于棘层肥厚的表皮中。在初期皮损中，CD1a+细胞占真皮层浸润细胞的50%-60%，在某些病例中，它们优先定位于乳头真皮上部，靠近基底位置的表皮CD1a+细胞，而在慢性银屑病中，它们所占比例不到10%。这些结果表明，在寻常型银屑病中，CD1a+细胞在表皮和真皮血管之间活跃迁移。
