Mark J, Dahlenfors R, Havel G, Böckmann P
Department of Pathology and Cytogenetics, Central Hospital, Skövde, Sweden.
Anticancer Res. 1991 Sep-Oct;11(5):1735-7.
This report concerns the first cytogenetical study of a benign salivary gland oncocytoma. The cultured tumor was studied in five consecutive preparations. The first three were dominated by cells with a normal karyotype. In the two subsequent preparations a hyperdiploid stemline characterized by trisomy 7 had taken over. Trisomy 7 has previously been observed in a number of different, benign, premalignant and malignant conditions. We interpreted trisomy 7 in the salivary gland oncocytoma, as in these other conditions, to be a neoplasia-related, probably primary, gross chromosomal change and not an expression of aging or comparable events in normal cells.
本报告涉及对良性涎腺嗜酸性细胞瘤的首次细胞遗传学研究。对培养的肿瘤进行了连续五次制片研究。前三张制片中以具有正常核型的细胞为主。在随后的两张制片中，以7号染色体三体为特征的超二倍体主干系占据主导。7号染色体三体先前已在多种不同的良性、癌前和恶性病变中观察到。我们将涎腺嗜酸性细胞瘤中的7号染色体三体解释为，与其他病变情况一样，是一种与肿瘤形成相关的、可能是原发性的染色体总体改变，而非正常细胞衰老或类似事件的表现。
