Mark J, Dahlenfors R, Stenman G, Nordquist A
Department of Pathology, Central Hospital, Skövde, Sweden.
Cancer Genet Cytogenet. 1990 May;46(1):35-9. doi: 10.1016/0165-4608(90)90006-v.
The cytogenetical observations in eight successfully cultured human adenolymphomas are reported. When the results were considered with those of two previously reported cases, three main stemline groups could be distinguished: (a) one with a normal karyotype and noted as a primary or secondary stemline in all hitherto studied tumors; (b) a second group with only numerical changes, either loss of the Y chromosome or trisomy or monosomy 5; and (c) a third group with only structural changes, as a rule with one or two reciprocal translocations. With regard to the last group, studies of many more cases are necessary to decide whether distinctive subgroups exist. Analyses using molecular methods are also urgently needed to clarify whether the normal stemline cells contain submicroscopic changes.
本文报告了8例成功培养的人类腺淋巴瘤的细胞遗传学观察结果。将这些结果与之前报道的2例病例的结果相结合时，可以区分出三个主要的主干系组：(a) 一组具有正常核型，在所有迄今为止研究的肿瘤中被视为主要或次要主干系；(b) 第二组仅存在数量变化，即Y染色体缺失、三体性或5号染色体单体性；(c) 第三组仅存在结构变化，通常有一或两个相互易位。关于最后一组，需要研究更多病例才能确定是否存在独特的亚组。还迫切需要使用分子方法进行分析，以阐明正常主干系细胞是否包含亚显微变化。
