Song Yan-li, Wu Xian-zheng, Guo Gang, Zhang Hai-xia, Yang Yi-qing
Department of Emergency, Tongji Hospital, Tongji University, Shanghai, 200065 P. R. China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Aug;24(4):422-4.
To investigate the relation between the 389A/G polymorphism in the human beta 1-adrenergic receptor and acute myocardial infarction (AMI).
Polymerase chain reaction amplification and restriction fragment length polymorphism analysis were used to detect the genotypes of 150 patients with AMI and 150 age- and sex- matched control subjects, and relative clinical data were obtained. A case-control study and multiple Logistic regression analysis were performed to assess the association between 389A/G polymorphism and AMI.
The distributions of the genotypes and allele frequencies were significantly different between two groups (P< 0.01). The prevalence of the A allele was significantly higher in patients with AMI than in control subjects. In the multivariate regression analysis, the 389A/G polymorphism (OR: 2.88, 95%CI: 1.70-4.88, P< 0.01), smoking(OR: 2.72, 95%CI: 1.52-4.88, P< 0.01), hyperlipidemia (OR: 2.85, 95%CI: 1.68-4.86, P< 0.01), diabetes mellitus(OR: 2.38, 95%CI: 1.27-4.47, P< 0.01) and hypertension (OR: 2.00, 95%CI: 1.62-3.45, P< 0.05) were independent risk factors of AMI.
The 389A/G polymorphism in the human beta 1-adrenergic receptor is associated with AMI and is an independent risk factor of AMI.
研究人类β1-肾上腺素能受体389A/G多态性与急性心肌梗死（AMI）之间的关系。
采用聚合酶链反应扩增和限制性片段长度多态性分析检测150例AMI患者及150例年龄、性别匹配的对照者的基因型，并获取相关临床资料。进行病例对照研究和多因素Logistic回归分析，以评估389A/G多态性与AMI的关联。
两组间基因型和等位基因频率分布差异有统计学意义（P<0.01）。AMI患者中A等位基因的患病率显著高于对照组。多因素回归分析显示，389A/G多态性（OR：2.88，95%CI：1.70-4.88，P<0.01）、吸烟（OR：2.72，95%CI：1.52-4.88，P<0.01）、高脂血症（OR：2.85，95%CI：1.68-4.86，P<0.01）、糖尿病（OR：2.38，95%CI：1.27-4.47，P<0.01）和高血压（OR：2.00，95%CI：1.62-3.45，P<0.05）是AMI的独立危险因素。
人类β1-肾上腺素能受体389A/G多态性与AMI相关，是AMI的独立危险因素。
