Propper C, Willoughby M, Halpern C T, Carbone M A, Cox M
Center for Developmental Science, University of North Carolina-Chapel Hill, CB# 8115, 100 East Franklin Street, Chapel Hill, NC 27599-811, USA.
Dev Psychobiol. 2007 Sep;49(6):619-32. doi: 10.1002/dev.20249.
Recent research has found that the dopamine D4 receptor (DRD4) gene and maternal insensitivity may interact to predict externalizing behavior in preschoolers. The current study attempted to replicate and extend this finding in a sample of 18-30-month-old children. The current study examined two distinct dimensions of parenting (warm-responsive and negative-intrusive) as predictors of childhood externalizing and internalizing behavior. Further, race was investigated as a moderator of gene-environment relationships. Results revealed that high warm-responsive parenting was associated with decreased externalizing behavior only for African American children possessing the short polymorphism of DRD4. The data indicate that children may be differentially susceptible to different aspects of parenting depending on their genotype, and it is important to consider differences in racial composition when studying these relationships.
近期研究发现，多巴胺D4受体（DRD4）基因与母亲的冷漠可能相互作用，以预测学龄前儿童的外化行为。本研究试图在18至30个月大的儿童样本中复制并扩展这一发现。本研究考察了养育方式的两个不同维度（温暖响应型和消极侵扰型）作为儿童外化和内化行为的预测因素。此外，还研究了种族作为基因-环境关系的调节因素。结果显示，只有拥有DRD4短多态性的非裔美国儿童，高温暖响应型养育方式才与外化行为减少有关。数据表明，儿童可能因其基因型不同而对养育方式的不同方面有不同的易感性，在研究这些关系时考虑种族构成的差异很重要。
