Bakermans-Kranenburg Marian J, van Ijzendoorn Marinus H
Center for Child and Family Studies, Leiden University, The Netherlands.
Dev Psychobiol. 2006 Jul;48(5):406-9. doi: 10.1002/dev.20152.
Previous studies have related aggression and other externalizing problems in children to either dopamine D4 receptor polymorphisms or harsh and insensitive parenting. In this study it was determined whether the combination of the DRD4 7-repeat polymorphism and maternal insensitivity predicted significantly more externalizing behavior in preschoolers. The results pointed to a gene-environment interaction effect: maternal insensitivity was associated with externalizing (oppositional, aggressive) behaviors, but only in the presence of the DRD4 7-repeat polymorphism. The increase in externalizing behaviors in children with the 7-repeat allele exposed to insensitive care compared to children without these combined risks was sixfold. The data indicate that children are differentially susceptible to insensitive parenting dependent on the presence of the 7-repeat DRD4 allele.
先前的研究已将儿童的攻击性及其他外化问题与多巴胺D4受体基因多态性或严厉且冷漠的养育方式联系起来。在本研究中，我们探究了DRD4基因7次重复多态性与母亲冷漠的组合是否能显著预测学龄前儿童更多的外化行为。结果表明存在基因-环境交互效应：母亲的冷漠与外化（对立、攻击）行为有关，但仅在存在DRD4基因7次重复多态性的情况下。与没有这些综合风险的儿童相比，携带7次重复等位基因且遭受冷漠照料的儿童外化行为增加了六倍。数据表明，根据是否存在DRD4基因7次重复等位基因，儿童对冷漠养育方式的易感性存在差异。
