Treudler Regina, Simon Jan C
Department of Dermatology, niversitätsklinikum Leipzig A.ö.R, Leipzig 04103, Germany.
Contact Dermatitis. 2007 Sep;57(3):177-80. doi: 10.1111/j.1600-0536.2007.01195.x.
Contact allergies to orthopaedic implant material are discussed to be relevant for postoperative complaints. We aimed at determining the prevalence of sensitizations to implant metals and to bone cements in patients with implants. We investigated 13 consecutive patients with suspicion of contact allergy to implant material. Epicutaneous patch testing was performed with metals and bone cement components including benzoyl peroxide (BPO). The chief complaints were skin disorders (n = 3), loosening of implant (n = 2), swelling (n = 6), and pain (n = 2). 6 patients had a sensitization to at least 1 allergen. 3 patients reacted to BPO, being of possible relevance in 1 of these patients suffering from dermatitis. Other sensitizations, such as those to nickel, fragrance, and balsam of Peru, were observed, with no clinical relevance (n = 1, respectively). BPO in bone cements may lead to type 4 sensitizations of which the relevance, however, remains questionable. Nevertheless we recommend this allergen to be tested in patients with complicated cemented orthopaedic implants.
接触性过敏对骨科植入材料的影响与术后并发症相关。我们旨在确定植入物患者对植入金属和骨水泥的致敏率。我们对13例疑似对植入材料有接触性过敏的患者进行了调查。采用包括过氧化苯甲酰（BPO）在内的金属和骨水泥成分进行皮肤斑贴试验。主要症状为皮肤疾病（n = 3）、植入物松动（n = 2）、肿胀（n = 6）和疼痛（n = 2）。6例患者对至少1种过敏原致敏。3例患者对BPO有反应，其中1例患有皮炎的患者可能与之相关。还观察到其他致敏情况，如对镍、香料和秘鲁香脂的致敏，但无临床相关性（分别为n = 1）。骨水泥中的BPO可能导致4型致敏，但其相关性仍存在疑问。尽管如此，我们建议对接受复杂骨水泥固定骨科植入物的患者进行该过敏原检测。
