类风湿性关节炎患者滑液新鲜样本中α1抗胰蛋白酶弹性蛋白酶抑制活性的失活。
Inactivation of the elastase inhibitory activity of alpha 1 antitrypsin in fresh samples of synovial fluid from patients with rheumatoid arthritis.
作者信息
Chidwick K, Winyard P G, Zhang Z, Farrell A J, Blake D R
机构信息
Inflammation Group, London Hospital Medical College, UK.
出版信息
Ann Rheum Dis. 1991 Dec;50(12):915-6. doi: 10.1136/ard.50.12.915.
Abstract
The proteinase inhibitory ability of alpha 1 antitrypsin was measured in 23 samples of rheumatoid arthritis synovial fluid, eight osteoarthritic synovial fluids and nine normal control serum samples. For each sample a detailed kinetic analysis was performed with porcine pancreatic elastase as the target proteinase. Samples were stored for less than 24 hours at 4 degrees C before analysis, which does not significantly alter the proportion of inactive alpha 1 antitrypsin. In rheumatoid synovial fluid the elastase inhibitory ability was disproportionately depressed relative to the immunochemically determined concentrations of alpha 1 antitrypsin.
摘要
在23份类风湿性关节炎滑液样本、8份骨关节炎滑液样本和9份正常对照血清样本中测定了α1抗胰蛋白酶的蛋白酶抑制能力。对于每个样本，以猪胰弹性蛋白酶作为靶蛋白酶进行了详细的动力学分析。分析前，样本在4℃下保存少于24小时，这不会显著改变无活性α1抗胰蛋白酶的比例。在类风湿性滑液中，相对于免疫化学测定的α1抗胰蛋白酶浓度，弹性蛋白酶抑制能力被不成比例地抑制。
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本文引用的文献
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Quantitation of human leukocyte elastase, cathepsin G, alpha-2-macroglobulin and alpha-1-proteinase inhibitor in osteoarthrosis and rheumatoid arthritis synovial fluids.骨关节炎和类风湿性关节炎滑液中人类白细胞弹性蛋白酶、组织蛋白酶G、α-2-巨球蛋白和α-1-蛋白酶抑制剂的定量分析
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