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全胃切除术后长期营养支持的效果

Effects of nutritional support long time after total gastrectomy.

作者信息

Copland Lotta, Liedman Bengt, Rothenberg Elisabet, Bosaeus Ingvar

机构信息

Department of Clinical Nutrition, Sahlgrenska University Hospital, S-413 45 Gothenburg, Sweden.

出版信息

Clin Nutr. 2007 Oct;26(5):605-13. doi: 10.1016/j.clnu.2007.06.004. Epub 2007 Aug 2.

Abstract

BACKGROUND & AIMS: Long-term effects of total gastrectomy on nutritional status are not well known, neither is the role of nutritional support. Dietary counselling is usually individualized, but generally not well defined. We aimed to evaluate effects of individualized oral nutritional support long time after total gastrectomy.

METHODS

Dietary advice was given, aiming for an energy and protein rich diet, using ordinary food and liquid supplements tailored to individual needs and preferences. Counselling was repeated monthly. Body weight and a 4-day food record were obtained at baseline, and thereafter-at month 1, 3, 6 and 12. Body composition, resting and total energy expenditure were measured at baseline and at 12 months.

RESULTS

Thirteen of 15 included patients completed the study. Though a trend of weight gain was seen after 1 month, there was no significant weight change at 12 months as weight development was quite heterogeneous. Six patients who remained healthy during the study (all with BMI<25) gained weight (p<0.05), while five patients with intercurrent co-morbidity and two with initial BMI>25 lost weight or remained stable.

CONCLUSIONS

Nutritional intervention long time after total gastrectomy did not change body weight, body composition or energy metabolism. Intercurrent co-morbidity appeared to have a major impact on outcome, as the nutritional support was more effective in patients who remained healthy and had a BMI<25.

摘要

背景与目的

全胃切除术后对营养状况的长期影响尚不明确,营养支持的作用也不清楚。饮食咨询通常是个性化的,但一般定义不明确。我们旨在评估全胃切除术后长期进行个性化口服营养支持的效果。

方法

提供饮食建议,目标是富含能量和蛋白质的饮食,使用根据个体需求和偏好定制的普通食物和液体补充剂。每月重复咨询。在基线时获取体重和4天的饮食记录,此后在第1、3、6和12个月时获取。在基线和12个月时测量身体成分、静息能量消耗和总能量消耗。

结果

15名纳入患者中有13名完成了研究。虽然在1个月后可见体重增加趋势,但在12个月时体重没有显著变化,因为体重变化相当不均匀。6名在研究期间保持健康的患者(所有人体重指数<25)体重增加(p<0.05),而5名有并发疾病的患者和2名初始体重指数>25的患者体重减轻或保持稳定。

结论

全胃切除术后长期的营养干预并未改变体重、身体成分或能量代谢。并发疾病似乎对结果有重大影响,因为营养支持在保持健康且体重指数<25的患者中更有效。

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