苯氟隆代谢产物对P388和艾氏腹水癌细胞糖酵解及巯基水平的影响。
Effects of benfluron metabolites on glycolysis and level of thiol groups in P388 and Ehrlich ascites cells.
作者信息
Miko M, Krepelka J, Mĕlka M, Vajdová D
机构信息
Department of Microbiology and Biochemistry, Slovak Polytechnical University, Bratislava, Czechoslovakia.
出版信息
Neoplasma. 1989;36(3):305-15.
The effects of two benfluron metabolites, namely 7-dihydrobenfluron (DBF) and N-oxide of benfluron (NOBF), on the aerobic glycolysis of Ehrlich ascites carcinoma (EAC) and P388 cells were studied. Also their effect on the level of total (T-SH) and nonprotein (NP-SH) thiol groups was investigated. A significant inhibition of aerobic glycolysis in the presence of NOBF was found only in P388 cells. Both metabolites decreased more significantly the level of NP-SH than that of T-SH.
研究了两种苄氟隆代谢物，即7-二氢苄氟隆（DBF）和苄氟隆N-氧化物（NOBF）对艾氏腹水癌（EAC）和P388细胞有氧糖酵解的影响。还研究了它们对总巯基（T-SH）和非蛋白质巯基（NP-SH）水平的影响。仅在P388细胞中发现，在存在NOBF的情况下有氧糖酵解受到显著抑制。两种代谢物使NP-SH水平降低的幅度比T-SH水平更显著。
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