Cauchi M N, Pepperell R, Kloss M, Lim D
Royal Women's Hospital, Carlton, Melbourne, Australia.
Am J Reprod Immunol. 1991 Sep;26(2):72-5. doi: 10.1111/j.1600-0897.1991.tb00974.x.
Factors that may have a bearing on subsequent pregnancy success or failure in patients with recurrent abortion were examined in 165 women with a history of three or more consecutive miscarriages in the first trimester. The overall success rate was 67.9%. Factors that were found to correlate significantly with success rate were length of abortion history, total number of abortions, interval from last miscarriage to present pregnancy, and whether there was any degree of subfertility. Logistic regression analysis showed that the abortion x years index and maternal age accounted for all the variation observed in our data. Where all other known causes of abortions are excluded, recurrent aborters can be subdivided into two populations--namely, those with a relatively good prognosis characterized by a short abortion history and absence of subfertility problems, compared to those with a poor prognosis namely those with a long abortion history or presence of subfertility problems. These data clearly demonstrate major differences in success rates in women depending on the number of abortions and the length of abortion history (abortion x year index), particularly in women over the age of 30 years.
对165名有孕早期连续三次或更多次流产史的女性进行了研究，探讨了可能影响复发性流产患者后续妊娠成败的因素。总体成功率为67.9%。发现与成功率显著相关的因素有流产病史时长、流产总数、从上一次流产到本次妊娠的间隔时间，以及是否存在任何程度的生育力低下。逻辑回归分析表明，流产年限指数和母亲年龄解释了我们数据中观察到的所有变异。在排除所有其他已知的流产原因后，复发性流产者可分为两类人群——即预后相对较好的人群，其特点是流产病史短且无生育力低下问题；与之相比，预后较差的人群即流产病史长或存在生育力低下问题的人群。这些数据清楚地表明，女性的成功率因流产次数和流产病史时长（流产年限指数）而存在重大差异，尤其是30岁以上的女性。
