Liu Hongzhuo, Wang Yongjun, Li Sanming
Pharmaceutical University of Shenyang, School of Pharmaceutics, Shenyang 110016, P. R. China.
Expert Opin Drug Deliv. 2007 Jul;4(4):349-58. doi: 10.1517/17425247.4.4.349.
Ciclosporin A has been used as an immunosuppressor for organ transplantation and other autoimmune disorders for a number of years. Its poor biopharmaceutical characteristics of low solubility and permeability makes the uphill task of designing delivery systems even more challenging for the drug delivery scientist. Works have been performed to investigate administration through various body routes, and have employed approaches that use as emulsions, microspheres, nanoparticles, liposomes, physical and chemical penetration enhancers. Although progress has been made, there is still room for improvement in the application of ciclosporin A, as none of these formulations is ideal.
环孢素A作为一种免疫抑制剂用于器官移植和其他自身免疫性疾病已有数年。其低溶解度和低渗透性这种较差的生物药剂学特性，使得药物递送科学家在设计给药系统这项艰巨任务上面临更大挑战。已经开展了多项工作来研究通过各种身体途径给药，并采用了如乳剂、微球、纳米颗粒、脂质体、物理和化学渗透促进剂等方法。尽管已经取得了进展，但环孢素A的应用仍有改进的空间，因为这些制剂都不理想。
