Internal Medicine, Department of Clinical Medicine and Emerging Diseases, University Hospital of Palermo, Via del Vespro, 141-90146, Palermo, Italy.
Clin Exp Med. 2012 Sep;12(3):201-5. doi: 10.1007/s10238-011-0158-1. Epub 2011 Sep 9.
The gastrointestinal tract of healthy individuals is colonized by hundreds of saprophytes and mycetes, especially the Candida species, are habitual ones. Under certain conditions, the fungal flora may overgrow, resulting in lesions of the digestive mucosa which, rarely, can have a local diffusion and/or spread to the lympho-hematogenous system. Mycotic infections of the stomach can sometimes look like benign gastric ulcers. Here, we present the case report of a woman, aged 64, who presented with type II diabetes mellitus and psoriasis, on chronic treatment with cyclosporin A and with endoscopic evidence of an ulcerated, vegetating gastric lesion secondary to Candida albicans infection. Although strongly suggestive of malignancy, it completely healed after cyclosporin withdrawal and the administration of oral antifungal drugs.
健康个体的胃肠道定植有数百种腐生菌和真菌，尤其是念珠菌属，是其常见菌属。在某些条件下，真菌菌群可能过度生长，导致消化黏膜出现病变，极少数情况下，这些病变可能具有局部扩散和/或扩散到淋巴血液系统的倾向。胃部真菌感染有时可能类似于良性胃溃疡。在此，我们报告了一例 64 岁女性患者，患有 2 型糖尿病和银屑病，长期接受环孢素 A 治疗，内镜下可见溃疡性、增生性胃病变，继发于白念珠菌感染。尽管强烈提示恶性肿瘤，但在停用环孢素和口服抗真菌药物治疗后，病变完全愈合。
