内皮细胞在器官发生中的作用：对亚里士多德古老概念的现代重新评估。
Contribution of endothelial cells to organogenesis: a modern reappraisal of an old Aristotelian concept.
作者信息
Crivellato E, Nico B, Ribatti D
机构信息
Department of Medical and Morphological Research, Anatomy Section, University of Udine, Italy.
出版信息
J Anat. 2007 Oct;211(4):415-27. doi: 10.1111/j.1469-7580.2007.00790.x. Epub 2007 Aug 7.
Abstract
It is well established that many tissue-derived factors are involved in blood vessel formation, but evidence is now emerging that endothelial cells themselves represent a crucial source of instructive signals to non-vascular tissue cells during organ development. Thus, endothelial cell signalling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodelling. This review article summarizes some of the recent advances in our understanding of the role of endothelial cells as effector cells in organ formation.
摘要
众所周知，许多组织衍生因子参与血管形成，但现在有证据表明，在内脏器官发育过程中，内皮细胞自身是向非血管组织细胞传递指导性信号的关键来源。因此，目前认为内皮细胞信号传导可促进细胞命运决定、胚胎模式形成、器官分化及出生后组织重塑的基本信号。这篇综述文章总结了我们对内皮细胞作为效应细胞在器官形成中作用的理解的一些最新进展。
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