Elmslie R E, Ogilvie G K, Dow S W, Gasper P, Hoover E A, Cooper M F, Pearson F C
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.
Mol Biother. 1991 Dec;3(4):231-8.
Normal feline bone marrow-derived macrophages released maximum concentrations of interleukin-6, tumor necrosis factor, and interleukin-1 when stimulated with ImuVert (Cell Technology Inc, Boulder, CO, USA) at dosages of 1.0 microgram/ml, 5.0 micrograms/ml, and 10.0 micrograms/ml, respectively. When ImuVert was administered to healthy adult cats, significant elevations in rectal temperature and neutrophil counts were observed 10 and 24 hours after each treatment. Weekly treatment with ImuVert failed to prevent or reverse viremia in cats when initiated prior to or 6 weeks after inoculation with feline leukemia virus.
正常猫骨髓来源的巨噬细胞在分别用1.0微克/毫升、5.0微克/毫升和10.0微克/毫升剂量的ImuVert（美国科罗拉多州博尔德市细胞技术公司）刺激时，会释放出白细胞介素-6、肿瘤坏死因子和白细胞介素-1的最大浓度。当给健康成年猫施用ImuVert时，每次治疗后10小时和24小时观察到直肠温度和中性粒细胞计数显著升高。当在接种猫白血病病毒之前或之后6周开始用ImuVert进行每周治疗时，未能预防或逆转猫的病毒血症。
