Nishino Naonobu, Tamori Yoshikazu, Kasuga Masato
Division of Diabetes and Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Kobe J Med Sci. 2007;53(3):99-106.
White adipose tissue (WAT) is important as an energy reservoir in mammals, but the precise mechanism by which energy storage in WAT is controlled remains unclear. It is well known that representative anabolic hormone insulin efficiently stores triglyceride in adipocytes. We showed that insulin inhibited beta-agonist-induced lipolysis at least in part by inhibiting phosphorylation of perilipin and hormone-sensitive lipase (HSL) in 3T3-L1 adipocytes. Furthermore, insulin inhibited beta-agonist-induced increase of PGC-1alpha expression, which is important for mitochondrial biogenesis and energy expenditure. These results suggest the possibility that insulin efficiently stores triglyceride in adipocytes by decreasing lipolysis and repressing energy expenditure.
白色脂肪组织（WAT）作为哺乳动物的能量储存库很重要，但WAT中能量储存的精确控制机制仍不清楚。众所周知，典型的合成代谢激素胰岛素能有效地将甘油三酯储存于脂肪细胞中。我们发现，胰岛素至少部分通过抑制3T3-L1脂肪细胞中围脂滴蛋白和激素敏感性脂肪酶（HSL）的磷酸化来抑制β-激动剂诱导的脂解。此外，胰岛素抑制β-激动剂诱导的PGC-1α表达增加，而PGC-1α对线粒体生物发生和能量消耗很重要。这些结果提示，胰岛素可能通过减少脂解和抑制能量消耗，有效地将甘油三酯储存于脂肪细胞中。
