Schutta Mark H
Rodebaugh Diabetes Center, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
J Cardiometab Syndr. 2007 Spring;2(2):124-30. doi: 10.1111/j.1559-4564.2007.06368.x.
Diabetes and hypertension frequently coexist, leading to additive increases in the risk of life-threatening cardiovascular events. Hypertension is a common comorbid condition in patients with type 1 or type 2 diabetes when compared with the general population and occurs in 75% of patients with the more prevalent form of diabetes, type 2. Arterial blood pressure plays an important role in the development of renal damage and presents a complex relationship. It is well-known that hypertension accelerates the course of microvascular and macrovascular complications of diabetes and that hypertension often precedes type 2 diabetes and vice versa. Patients with type 1 and 2 diabetes and nephropathy frequently have circadian changes in blood pressure that correlate to nephropathy risk. Early detection of nocturnal hypertension and early intervention with angiotensin blockade may delay progression of diabetic nephropathy.
糖尿病和高血压常常并存，导致危及生命的心血管事件风险叠加增加。与普通人群相比，高血压是1型或2型糖尿病患者常见的合并症，在更为常见的2型糖尿病患者中，75%的患者患有高血压。动脉血压在肾损害的发生中起重要作用，且呈现出复杂的关系。众所周知，高血压会加速糖尿病微血管和大血管并发症的进程，而且高血压常常先于2型糖尿病出现，反之亦然。1型和2型糖尿病及肾病患者的血压常常有昼夜变化，这与肾病风险相关。早期发现夜间高血压并早期采用血管紧张素阻断进行干预，可能会延缓糖尿病肾病的进展。
