Hoffmeister S A
Zentrum für Molekulare Biologie, Heidelberg, F.R.G.
Mech Dev. 1991 Nov;35(3):181-92. doi: 10.1016/0925-4773(91)90017-z.
A foot regeneration deficient strain of Hydra oligactis with altered size regulation was investigated. Analysis of the concentration of four morphogenetically active substances in Hydra oligactis showed that the foot regeneration deficiency was mainly due to a drastically reduced foot activator concentration. Foot activator was distributed as a very steep gradient in Hydra oligactis leading to a more severe impairment of foot regeneration the closer to the head cutting was done. The concentration of foot inhibitor was comparable, that of head activator slightly increased and that of head inhibitor reduced compared to Hydra vulgaris. Studies at the cellular level implied that the enlarged gastric region was due to an elevated level of inhibition hinting at a shift in the ratio between bound and free head inhibitor in this animal.
对一种体型调控改变的少枝螅足部再生缺陷菌株进行了研究。对少枝螅中四种形态发生活性物质的浓度分析表明，足部再生缺陷主要是由于足部激活剂浓度急剧降低所致。足部激活剂在少枝螅中呈非常陡峭的梯度分布，离头部切割部位越近，足部再生的损伤就越严重。与普通螅相比，足部抑制剂的浓度相当，头部激活剂的浓度略有增加，而头部抑制剂的浓度则降低。细胞水平的研究表明，胃部区域扩大是由于抑制水平升高，这暗示了该动物体内结合型和游离型头部抑制剂比例的变化。
