Schmidt T, Schaller H C
Cell Differ. 1976 Oct;5(3):151-9. doi: 10.1016/0045-6039(76)90017-8.
Crude extracts of hydra contain a substance or substances which specifically inhibit foot formation in regenerating hydra. This foot inhibitor(s) is probably of low molecular weight, and it is present in the animal in an inactive, structure-bound form as a gradient from foot to head. The foot region contains 60% of this inhibitor in a 7-8 fold higher concentration than the other regions. The foot inhibitor was purified chemically from the head activator (Schaller, 1973) and the 'head' inhibitor (Berking, 1974). It is suggested that the substance under investigation is a new morphogen, responsible for foot inhibition in hydra.
水螅的粗提取物含有一种或多种能特异性抑制再生水螅足部形成的物质。这种足部抑制剂可能分子量较低，在动物体内以无活性的、与结构结合的形式存在，从足部到头部呈梯度分布。足部区域含有这种抑制剂的60%，其浓度比其他区域高7至8倍。足部抑制剂是从头部激活剂（沙勒，1973年）和“头部”抑制剂（伯金，1974年）中通过化学方法纯化得到的。有人认为所研究的这种物质是一种新的形态发生素，负责水螅的足部抑制。
