Tejada Thor, Fornoni Alessia, Lenz Oliver, Materson Barry J
Division of Nephrology and Hypertension, Department of Medicine, Miller School of Medicine, University of Miami OPPRP (D-54), PO Box 016960, Miami, FL 33101, USA.
Curr Hypertens Rep. 2007 Aug;9(4):284-90. doi: 10.1007/s11906-007-0052-0.
Amlodipine is a highly effective and safe antihypertensive dihydropyridine calcium channel blocker. It is even more effective when used in combination with other antihypertensive medications, including hydrochlorothiazide. When antihypertensive calcium channel blockers were first introduced, evidence in the laboratory that they had some natriuretic properties was adduced to suggest that they would be "the diuretics of the 1990s." This turned out not to be the case. Because of its clinical efficacy, amlodipine is frequently used in fixed-dose combination products, but it is not likely to replace hydrochlorothiazide.
氨氯地平是一种高效且安全的抗高血压二氢吡啶类钙通道阻滞剂。与包括氢氯噻嗪在内的其他抗高血压药物联合使用时，它的效果更佳。当抗高血压钙通道阻滞剂首次被引入时，实验室证据表明它们具有一定的利钠特性，据此有人提出它们将成为“20世纪90年代的利尿剂”。但事实并非如此。由于其临床疗效，氨氯地平经常被用于固定剂量复方制剂中，但它不太可能取代氢氯噻嗪。
