Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, Rokietnicka 3 Str., 60-806 Poznań, Poland.
Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers-The State University of New Jersey, Piscataway, NJ 08854, USA.
Molecules. 2024 Jun 20;29(12):2938. doi: 10.3390/molecules29122938.
Chronic wound treatments pose a challenge for healthcare worldwide, particularly for the people in developed countries. Chronic wounds significantly impair quality of life, especially among the elderly. Current research is devoted to novel approaches to wound care by repositioning cardiovascular agents for topical wound treatment. The emerging field of medicinal products' repurposing, which involves redirecting existing pharmaceuticals to new therapeutic uses, is a promising strategy. Recent studies suggest that medicinal products such as sartans, beta-blockers, and statins have unexplored potential, exhibiting multifaceted pharmacological properties that extend beyond their primary indications. The purpose of this review is to analyze the current state of knowledge on the repositioning of cardiovascular agents' use and their molecular mechanisms in the context of wound healing.
慢性伤口治疗是全球医疗保健面临的挑战，特别是在发达国家。慢性伤口严重影响生活质量，尤其是老年人。目前的研究致力于通过重新定位心血管药物进行局部伤口治疗来寻找新的方法。重新定位现有药物以实现新的治疗用途的新兴药物再利用领域是一种很有前途的策略。最近的研究表明，沙他停、β-受体阻滞剂和他汀类药物等药物具有尚未开发的潜力，表现出超越其主要适应证的多方面药理特性。本文旨在分析心血管药物重新定位及其在伤口愈合中的分子机制的研究现状。
