Redon Josep, Cífková Renata
Hypertension Clinic, Internal Medicine, Hospital Clinico, University of Valencia, 46010 Valencia, Spain.
Curr Hypertens Rep. 2007 Aug;9(4):305-13. doi: 10.1007/s11906-007-0056-9.
Arterial hypertension is often part of a larger constellation of anthropometric and metabolic abnormalities that includes abdominal (or visceral) obesity, characteristic dyslipidemia (low high-density lipoprotein cholesterol and high triglyceride levels), glucose intolerance, insulin resistance, and hyperuricemia. Using National Cholesterol Education Program Adult Treatment Panel III criteria, prevalence is higher than in the general population and the metabolic syndrome can be found in as many as one third of patients. Among hypertensives with metabolic syndrome, a high prevalence of hypertension-induced target-organ damage and a poor prognostic value has been described. Dietary advice and lifestyle changes should be strongly recommended and prompt pharmacologic treatment is required to control high blood pressure and to reduce risk. The impact of particular antihypertensive drugs on other components of the metabolic syndrome is an important clinical issue with consequences for the success of treatment.
动脉高血压通常是一系列更大的人体测量和代谢异常的一部分，这些异常包括腹部（或内脏）肥胖、特征性血脂异常（高密度脂蛋白胆固醇水平低和甘油三酯水平高）、葡萄糖耐量异常、胰岛素抵抗和高尿酸血症。根据美国国家胆固醇教育计划成人治疗小组第三次报告的标准，其患病率高于普通人群，多达三分之一的患者可出现代谢综合征。在患有代谢综合征的高血压患者中，高血压引起的靶器官损害患病率高且预后不良。应强烈建议进行饮食建议和生活方式改变，并需要及时进行药物治疗以控制高血压并降低风险。特定抗高血压药物对代谢综合征其他组分的影响是一个重要的临床问题，对治疗的成功有影响。
