Jain Manish, Townsend Raymond R
Department of Medicine, University of Pennsylvania, 3400 Spruce Street, 1 Gibson, Philadelphia, PA 19104, USA.
Curr Hypertens Rep. 2007 Aug;9(4):320-8. doi: 10.1007/s11906-007-0058-7.
Two observations highlight the importance of this review. The first observation is that high blood pressure is the most frequent comorbid condition in cancer registries which directly affects the prognosis of the patient. The second observation is that long-term cancer survivors now have a higher risk of cardiovascular disease than of recurrent cancer, and hypertension contributes to this risk. New approaches to cancer chemotherapy disrupt angiogenesis; subjects receiving these agents often have an associated increase in blood pressure. In this article we concentrate on observations published over the past 2 years in this rapidly developing field, outline putative mechanisms and time frames for these prohypertensive effects, and conclude with some management recommendations based on current knowledge.
两项观察结果凸显了本综述的重要性。第一项观察结果是，高血压是癌症登记中最常见的合并症，直接影响患者的预后。第二项观察结果是，癌症长期幸存者现在患心血管疾病的风险高于癌症复发的风险，而高血压会导致这种风险。癌症化疗的新方法会破坏血管生成；接受这些药物治疗的患者血压通常会相应升高。在本文中，我们重点关注过去两年在这个快速发展的领域发表的观察结果，概述这些高血压效应的假定机制和时间框架，并根据现有知识给出一些管理建议作为结论。
