Chubinskaya Susan, Hurtig Mark, Rueger David C
Department of Biochemistry, Orthopedics and Section of Rheumatology (Department of Internal Medicine), Rush University Medical Center, Chicago, IL, 60612, USA.
Int Orthop. 2007 Dec;31(6):773-81. doi: 10.1007/s00264-007-0423-9. Epub 2007 Aug 9.
Three years ago we published a book chapter on the role of bone morphogenetic proteins (BMPs) in cartilage repair. Since that time our understanding of the function of osteogenic protein-1 (OP-1) or BMP-7 in cartilage homeostasis and repair has substantially improved and therefore we decided to devote a current review solely to this BMP. Here we summarise the information accumulated on OP-1 from in vitro and ex vivo studies with cartilage cells and tissues as well as from in vivo studies of cartilage repair in various animal models. The primary focus is on articular chondrocytes and cartilage, but data will also be presented on nonarticular cartilage, particularly from the intervertebral disc. The data show that OP-1 is a unique growth factor which, unlike other members of the same BMP family, exhibits in addition to its strong pro-anabolic activity very prominent anti-catabolic properties. Animal studies have demonstrated that OP-1 has the ability to repair cartilage in vivo in various models of articular cartilage degradation, including focal osteochondral and chondral defects and osteoarthritis, as well as models of degeneration in intervertebral disc cartilage. Together our findings indicate a significant promise for OP-1 as therapeutic in cartilage repair.
三年前，我们发表了一章关于骨形态发生蛋白（BMPs）在软骨修复中作用的书籍章节。从那时起，我们对成骨蛋白-1（OP-1）或BMP-7在软骨稳态和修复中的功能的理解有了显著提高，因此我们决定专门针对这种BMP进行当前的综述。在这里，我们总结了从软骨细胞和组织的体外和离体研究以及各种动物模型中软骨修复的体内研究中积累的关于OP-1的信息。主要关注关节软骨细胞和软骨，但也将展示来自非关节软骨的数据，特别是来自椎间盘的数据。数据表明，OP-1是一种独特的生长因子，与同一BMP家族的其他成员不同，它除了具有强大的促合成代谢活性外，还具有非常突出的抗分解代谢特性。动物研究表明，OP-1能够在各种关节软骨降解模型中，包括局灶性骨软骨和软骨缺损以及骨关节炎，以及椎间盘软骨退变模型中，在体内修复软骨。我们的研究结果共同表明，OP-1作为软骨修复治疗药物具有巨大的前景。
