Maher J F
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799.
J Am Soc Nephrol. 1991 Apr;1(10):1128-35. doi: 10.1681/ASN.V1101128.
Within a few years of its occurrence, American clinicians became aware of the discovery by Bright in 1827 that albuminuria in edematous patients was associated with granular degeneration of the kidney. Yet, there was a paucity of important original observations in nephrology from American in the first half of the 19th century. By the mid-19th century, however, the primitive concepts of clinical nephrology, renal physiology, and renal pathology were becoming established in the United States, after enlightenment from Europe. Because of the dreadful course of anasarca and uremia and stimulated by the advantages of innovations in microscopy, renal disease began at that time to attract the attention of eminent American clinician-pathologists. Their early observations would add to the knowledge base on which later developments such as bacteriology, radiology, clinical chemistry, and other scientific advances would build.
在这一发现出现后的几年内，美国临床医生就知晓了布莱特于1827年的发现，即水肿患者的蛋白尿与肾脏颗粒样变性有关。然而，在19世纪上半叶，美国在肾脏病学方面几乎没有重要的原创性观察。不过，到了19世纪中叶，在美国受到欧洲启发之后，临床肾脏病学、肾脏生理学和肾脏病理学的初步概念开始确立。由于全身性水肿和尿毒症的病程可怕，且受显微镜创新优势的刺激，肾脏疾病在那时开始引起美国著名临床病理学家的关注。他们早期的观察将为后来细菌学、放射学、临床化学等科学进展以及其他科学进步所构建的知识基础增添内容。
