Lazaris A C, Segas J V, Nikolopoulos T P, Patsouris E S
First Department of Pathology, School of medicine, National and Kapodistrian University of Athens, Athens, Greece.
Neoplasma. 2007;54(5):379-82.
Natural Killer (NK) cells have gained much attention as potential cells in antitumor immune defense mechanisms. In a group of 31 patients with surgically treated squamous cell laryngeal carcinoma, NK cell presence was semiquantitatively assessed by means of immunohistochemistry. A panel of three monoclonal antibodies including anti-CD16, was applied on frozen tissue sections. High CD 16+ cell presence was more frequently detected in poorly differentiated carcinomas (in 6 out of 14 cases) by comparison to carcinomas of high to moderate degrees of differentiation (in 1 out of 16 cases, p=0.031). No other clinicopathological variable appeared to influence NK cell presence in the examined specimens. No relation between NK cell detection and relapse-free survival emerged. Poorly differentiated laryngeal cancer cells appear to trigger off a greater NK cell tissue response than well and moderately differentiated cancer cells; however, the potential prognostic impact of this observation remains to be established.
自然杀伤（NK）细胞作为抗肿瘤免疫防御机制中的潜在细胞已备受关注。在一组31例接受手术治疗的喉鳞状细胞癌患者中，通过免疫组织化学方法对NK细胞的存在情况进行了半定量评估。一组包括抗CD16在内的三种单克隆抗体应用于冷冻组织切片。与高分化至中分化癌（16例中有1例，p = 0.031）相比，低分化癌（14例中有6例）中更频繁地检测到高CD16 +细胞的存在。在检查的标本中，没有其他临床病理变量似乎影响NK细胞的存在。NK细胞检测与无复发生存之间没有关系。低分化喉癌细胞似乎比高分化和中分化癌细胞引发更大的NK细胞组织反应；然而，这一观察结果的潜在预后影响仍有待确定。
