Nakase Taizen, Mizuno Toshiki, Harada Sanae, Yamada Kei, Nishimura Tsunehiko, Ozasa Kotaro, Watanabe Yoshiyuki, Nagata Ken
Department of Neurology, Research Institute for Brain and Blood Vessels, 6-10 Senshu Kubota Machi, Akita, Japan 010-0874.
J Clin Neurosci. 2007 Oct;14(10):943-7. doi: 10.1016/j.jocn.2006.07.008. Epub 2007 Aug 3.
While gene polymorphism for angiotensinogen (AGT) is reported to contribute to the regulation of blood pressure and salt sensitivity, its effect on the risk of ischemic stroke remains controversial. We hypothesized that polymorphism of the AGT gene could be a risk factor for ischemic stroke. Major clinical risk factors and the AGT gene M235T polymorphism were examined in 147 consecutive stroke patients and 133 healthy age-matched controls. All patients were categorized into four stroke types (single lacuna, multiple lacunae, large-artery atherosclerosis and branch atheromatous disease in brainstem) and two vascular groups (large and perforating arterial lesions). The AGT gene M allele significantly increased the risk of single lacuna, multiple lacunae and small arterial lesions, in male patients (p=0.029, 0.031 and 0.026, respectively). Synergistic effects of the AGT gene polymorphism and clinical risks were not observed. In conclusion, AGT M allele may present a risk of lacunar infarctions in Japanese men, independent of hypertension.
虽然据报道血管紧张素原（AGT）基因多态性有助于血压调节和盐敏感性，但它对缺血性中风风险的影响仍存在争议。我们假设AGT基因多态性可能是缺血性中风的一个危险因素。对147例连续的中风患者和133例年龄匹配的健康对照者进行了主要临床危险因素和AGT基因M235T多态性检测。所有患者被分为四种中风类型（单发腔隙性、多发腔隙性、大动脉粥样硬化和脑干分支动脉粥样硬化疾病）和两个血管组（大动脉和穿支动脉病变）。AGT基因M等位基因显著增加了男性患者单发腔隙性、多发腔隙性和小动脉病变的风险（p分别为0.029、0.031和0.026）。未观察到AGT基因多态性与临床风险的协同作用。总之，AGT M等位基因可能使日本男性出现腔隙性梗死的风险增加，且独立于高血压。
