Gao Tao, Huang Lina, Fu Qizhi, Bai Yongjie
Department of Neurology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, China.
Department of Neurology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, China
J Renin Angiotensin Aldosterone Syst. 2015 Sep;16(3):681-6. doi: 10.1177/1470320315583600. Epub 2015 May 5.
The angiotensinogen (AGT) gene polymorphisms has been shown to be involved in the development of ischemic stroke. However, the published studies have yielded inconsistent results. We performed a meta-analysis to assess the correlation.
Published literature from PubMed, EMBASE, CNKI and Wanfang Data was searched. The association was assessed by odds ratio (OR) with 95% confidence intervals (CI). Publication bias was also calculated.
Eight studies (1636 cases and 1433 controls) on M235T polymorphism and four studies (726 cases and 495 controls) on T174M polymorphism were included in the meta-analysis. The results showed that M235T polymorphism was significantly associated with risk of ischemic stroke risk (TT vs. MM: OR=2.60, 95% CI=1.77-3.83; MT vs. MM: OR=1.37, 95% CI=1.01-1.86; TT+MT vs. MM: OR=0.43, 95% CI=0.35-0.54; MM+MT vs. TT: OR=1.74, 95% CI=1.31-2.32). There was also significant association between T174M polymorphism and ischemic stroke risk (MM vs. TT: OR=3.66, 95% CI=1.89-7.08; TT+MT vs. MM: OR=0.28, 95% CI=0.14-0.54). Further sensitivity analysis confirmed the significant association between AGT gene polymorphisms and risk of ischemic stroke. No evidence indicated publication bias.
The meta-analysis indicated the significant association of AGT gene polymorphisms (M235T, T174M) with risk of ischemic stroke in the Chinese population.
血管紧张素原（AGT）基因多态性已被证明与缺血性脑卒中的发生有关。然而，已发表的研究结果并不一致。我们进行了一项荟萃分析以评估其相关性。
检索了来自PubMed、EMBASE、中国知网和万方数据的已发表文献。通过比值比（OR）及95%置信区间（CI）评估相关性。同时计算发表偏倚。
荟萃分析纳入了8项关于M235T多态性的研究（1636例病例和1433例对照）以及4项关于T174M多态性的研究（726例病例和495例对照）。结果显示，M235T多态性与缺血性脑卒中风险显著相关（TT与MM相比：OR = 2.60，95% CI = 1.77 - 3.83；MT与MM相比：OR = 1.37，95% CI = 1.01 - 1.86；TT + MT与MM相比：OR = 0.43，95% CI = 0.35 - 0.54；MM + MT与TT相比：OR = 1.74，95% CI = 1.31 - 2.32）。T174M多态性与缺血性脑卒中风险之间也存在显著关联（MM与TT相比：OR = 3.66，95% CI = 1.89 - 7.08；TT + MT与MM相比：OR = 0.28，95% CI = 0.14 - 0.54）。进一步的敏感性分析证实了AGT基因多态性与缺血性脑卒中风险之间的显著关联。没有证据表明存在发表偏倚。
荟萃分析表明AGT基因多态性（M235T、T174M）与中国人群缺血性脑卒中风险显著相关。
