Association of polymorphisms in the AGT gene(M235T, T174M) with ischemic stroke in the Chinese population.

OBJECTIVE

The angiotensinogen (AGT) gene polymorphisms has been shown to be involved in the development of ischemic stroke. However, the published studies have yielded inconsistent results. We performed a meta-analysis to assess the correlation.

METHODS

Published literature from PubMed, EMBASE, CNKI and Wanfang Data was searched. The association was assessed by odds ratio (OR) with 95% confidence intervals (CI). Publication bias was also calculated.

RESULTS

Eight studies (1636 cases and 1433 controls) on M235T polymorphism and four studies (726 cases and 495 controls) on T174M polymorphism were included in the meta-analysis. The results showed that M235T polymorphism was significantly associated with risk of ischemic stroke risk (TT vs. MM: OR=2.60, 95% CI=1.77-3.83; MT vs. MM: OR=1.37, 95% CI=1.01-1.86; TT+MT vs. MM: OR=0.43, 95% CI=0.35-0.54; MM+MT vs. TT: OR=1.74, 95% CI=1.31-2.32). There was also significant association between T174M polymorphism and ischemic stroke risk (MM vs. TT: OR=3.66, 95% CI=1.89-7.08; TT+MT vs. MM: OR=0.28, 95% CI=0.14-0.54). Further sensitivity analysis confirmed the significant association between AGT gene polymorphisms and risk of ischemic stroke. No evidence indicated publication bias.

CONCLUSIONS

The meta-analysis indicated the significant association of AGT gene polymorphisms (M235T, T174M) with risk of ischemic stroke in the Chinese population.