Materna Stefan C, Davidson Eric H
California Institute of Technology, Division of Biology, m/c 156-29, 1200 E. California Blvd., Pasadena, CA 91125, USA.
Curr Opin Biotechnol. 2007 Aug;18(4):351-4. doi: 10.1016/j.copbio.2007.07.008. Epub 2007 Aug 6.
Regulatory networks of transcription factors and signaling molecules lie at the heart of development. Their architecture implements logic functions whose execution propels cells from one regulatory state to the next, thus driving development forward. As an example of a subcircuit that translates transcriptional input into developmental output, we consider a particularly simple case, the regulatory processes underlying pigment cell formation in sea urchin embryos. The regulatory events in this process can be represented as elementary logic functions.
转录因子和信号分子的调控网络是发育的核心。它们的架构实现了逻辑功能,这些功能的执行将细胞从一种调控状态推向另一种调控状态,从而推动发育进程。作为一个将转录输入转化为发育输出的子电路的例子,我们考虑一个特别简单的情况,即海胆胚胎中色素细胞形成的调控过程。这个过程中的调控事件可以表示为基本逻辑功能。