棘皮动物胚胎基因调控网络的模块化和设计原则。
Modularity and design principles in the sea urchin embryo gene regulatory network.
机构信息
California Institute of Technology, Division of Biology, Pasadena, CA 91125, USA.
出版信息
FEBS Lett. 2009 Dec 17;583(24):3948-58. doi: 10.1016/j.febslet.2009.11.060.
Abstract
The gene regulatory network (GRN) established experimentally for the pre-gastrular sea urchin embryo provides causal explanations of the biological functions required for spatial specification of embryonic regulatory states. Here we focus on the structure of the GRN which controls the progressive increase in complexity of territorial regulatory states during embryogenesis; and on the types of modular subcircuits of which the GRN is composed. Each of these subcircuit topologies executes a particular operation of spatial information processing. The GRN architecture reflects the particular mode of embryogenesis represented by sea urchin development. Network structure not only specifies the linkages constituting the genomic regulatory code for development, but also indicates the various regulatory requirements of regional developmental processes.
摘要
海胆原肠胚期的基因调控网络（GRN）实验建立，为胚胎调控状态的空间特化所必需的生物学功能提供了因果解释。在这里，我们关注的是控制胚胎发生过程中领地调控状态复杂性逐渐增加的 GRN 结构；以及 GRN 所组成的模块化子电路的类型。这些子电路拓扑中的每一个都执行特定的空间信息处理操作。GRN 的体系结构反映了海胆发育所代表的特定胚胎发生模式。网络结构不仅指定了构成发育基因组调控代码的连接，还指示了区域发育过程的各种调控要求。
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