核糖体蛋白的平衡产生
Balanced production of ribosomal proteins.
作者信息
Perry Robert P
机构信息
Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
出版信息
Gene. 2007 Oct 15;401(1-2):1-3. doi: 10.1016/j.gene.2007.07.007. Epub 2007 Jul 18.
Abstract
Eukaryotic ribosomes contain one molecule each of 79 different proteins. The genes encoding these proteins are usually at widely scattered loci and have distinctive promoters with certain common features. This minireview discusses the means by which cells manage to balance the production of ribosomal proteins so as to end up with equimolar quantities in the ribosome. Regulation at all levels of gene expression, from transcription to protein turnover, is considered.
摘要
真核生物核糖体包含79种不同蛋白质，每种各一个分子。编码这些蛋白质的基因通常位于广泛分散的基因座上，并且具有带有某些共同特征的独特启动子。本综述讨论了细胞平衡核糖体蛋白产量以便在核糖体中最终获得等摩尔量的方式。从转录到蛋白质周转，基因表达各个水平的调控都在考虑范围内。
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本文引用的文献
1
Genetic interaction screens advance in reverse.
Genes Dev. 2007 Jan 15;21(2):137-42. doi: 10.1101/gad.1512707.
2
Weighing our measures of gene expression.
Mol Syst Biol. 2006;2:63. doi: 10.1038/msb4100096. Epub 2006 Nov 14.
3
Impaired ribosome biogenesis in Diamond-Blackfan anemia.
Blood. 2007 Feb 1;109(3):1275-83. doi: 10.1182/blood-2006-07-038372. Epub 2006 Oct 19.
4
Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation.
Mol Cell Biol. 2006 Dec;26(23):8880-91. doi: 10.1128/MCB.00751-06. Epub 2006 Sep 25.
5
Recent insights into the pathogenesis of Diamond-Blackfan anaemia.
Br J Haematol. 2006 Oct;135(2):149-57. doi: 10.1111/j.1365-2141.2006.06268.x. Epub 2006 Aug 31.
6
Fine-structure analysis of ribosomal protein gene transcription.
Mol Cell Biol. 2006 Jul;26(13):4853-62. doi: 10.1128/MCB.02367-05.
7
Characteristics and clustering of human ribosomal protein genes.
BMC Genomics. 2006 Feb 28;7:37. doi: 10.1186/1471-2164-7-37.
8
Association of ribosomal proteins with nascent transcripts in S. cerevisiae.
RNA. 2005 Oct;11(10):1521-9. doi: 10.1261/rna.2134305.
9
Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast.
Genetics. 2005 Apr;169(4):1915-25. doi: 10.1534/genetics.104.036871. Epub 2005 Feb 16.
10
The architecture of mammalian ribosomal protein promoters.
BMC Evol Biol. 2005 Feb 13;5:15. doi: 10.1186/1471-2148-5-15.
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