Ojewole John A O
Department of Pharmacology, School of Pharmacy & Pharmacology, Faculty of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa.
J Ethnopharmacol. 2007 Sep 5;113(2):338-45. doi: 10.1016/j.jep.2007.06.025. Epub 2007 Jul 7.
In an attempt to scientifically evaluate some of the anecdotal, folkloric, ethnomedical uses of Rhus chirindensis Baker F. ('red currant'), the present study was undertaken to investigate the analgesic, anti-inflammatory and hypoglycaemic effects of the plant's stem-bark aqueous extract (RCE) in mice and rats. The analgesic effect of RCE was evaluated by 'hot-plate' and 'acetic acid' analgesic test methods in mice; while its anti-inflammatory and hypoglycaemic effects were investigated in rats, using fresh egg albumin-induced pedal oedema, and streptozotocin (STZ)-induced diabetes mellitus animal models. Morphine (MPN, 10 mg/kg), diclofenac (DIC, 100 mg/kg) and chlorpropamide (250 mg/kg) were used as reference drugs for comparison. RCE (50-800 mg/kg i.p.) produced dose-dependent, significant (P<0.05-0.001) analgesic effects against thermally- and chemically-induced nociceptive pain in mice. The plant's extract (RCE, 50-800 mg/kg p.o.) also significantly (P<0.05-0.001) inhibited fresh egg albumin-induced acute inflammation, and caused dose-related, significant (P<0.05-0.001) hypoglycaemia in normal (normoglycaemic) and diabetic (hyperglycaemic) rats. The flavonoids, triterpenoids and other chemical compounds present in RCE are speculated to account for the observed pharmacological effects of the plant's extract in the experimental animal paradigms used. The findings of this experimental animal study indicate that Rhus chirindensis stem-bark aqueous extract possesses analgesic, anti-inflammatory and hypoglycaemic properties; and thus lend pharmacological credence to the anecdotal, folkloric, ethnomedical uses of the plant in the treatment and/or management of painful, arthritic, inflammatory conditions, as well as in the management and/or control of type 2 diabetes mellitus in some rural communities of South Africa.
为了科学评估刺果漆（“红醋栗”）的一些传闻、民间传说、民族医学用途，本研究旨在调查该植物茎皮水提取物（RCE）对小鼠和大鼠的镇痛、抗炎和降血糖作用。通过“热板”和“醋酸”镇痛试验方法评估RCE对小鼠的镇痛作用；同时，使用新鲜蛋清诱导的足肿胀和链脲佐菌素（STZ）诱导的糖尿病动物模型，在大鼠中研究其抗炎和降血糖作用。吗啡（MPN，10 mg/kg）、双氯芬酸（DIC，100 mg/kg）和氯磺丙脲（250 mg/kg）用作对照药物进行比较。RCE（50 - 800 mg/kg腹腔注射）对小鼠热诱导和化学诱导的伤害性疼痛产生剂量依赖性的显著（P < 0.05 - 0.001）镇痛作用。该植物提取物（RCE，50 - 800 mg/kg口服）也显著（P < 0.05 - 0.001）抑制新鲜蛋清诱导的急性炎症，并在正常（血糖正常）和糖尿病（高血糖）大鼠中引起剂量相关的显著（P < 0.05 - 0.001）低血糖。推测RCE中存在的黄酮类化合物、三萜类化合物和其他化合物是该植物提取物在所用实验动物模型中观察到的药理作用的原因。这项实验动物研究的结果表明，刺果漆茎皮水提取物具有镇痛、抗炎和降血糖特性；因此，从药理学角度证实了该植物在南非一些农村社区用于治疗和/或管理疼痛、关节炎、炎症性疾病以及管理和/或控制2型糖尿病的传闻、民间传说和民族医学用途。
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