Ojewole John A O, Adewole Stephen O
Department of Pharmacology, School of Pharmacy and Pharmacology, Faculty of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.
J Nat Med. 2009 Apr;63(2):117-23. doi: 10.1007/s11418-008-0298-0. Epub 2008 Dec 3.
In this study, we investigated the hypoglycaemic and antidiabetic properties of mollic acid glucoside (MAG), a 1alpha-hydroxycycloartenoid extractive from Combretum molle leaf, in rodents. Stepwise, escalated doses of MAG (5-80 mg/kg p.o.) produced dose-dependent and significant (P < 0.05-0.01) hypoglycaemic and antidiabetic effects in normal (normoglycaemic) and streptozotocin-treated diabetic rats. Experimental evidence obtained from this laboratory animal study indicates that MAG, an extractive from C. molle leaf, possesses hypoglycaemic and antidiabetic properties. These findings lend pharmacological credence to the folkloric, ethnomedical uses of the plant's leaf in the management and/or control of diabetes mellitus in some rural communities of southern Africa.
在本研究中，我们调查了从柔毛风车子叶中提取的1α-羟基环阿尔廷烯类化合物——莫利酸葡糖苷（MAG）在啮齿动物中的降血糖和抗糖尿病特性。逐步递增剂量的MAG（口服5-80mg/kg）在正常（血糖正常）和链脲佐菌素诱导的糖尿病大鼠中产生了剂量依赖性且显著（P<0.05-0.01）的降血糖和抗糖尿病作用。从这项实验动物研究中获得的实验证据表明，从柔毛风车子叶中提取的MAG具有降血糖和抗糖尿病特性。这些发现为该植物叶子在非洲南部一些农村社区用于管理和/或控制糖尿病的民间医学用途提供了药理学依据。
