Ojewole J A O
Department of Pharmacology, School of Pharmacy & Pharmacology, Faculty of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa.
Inflammopharmacology. 2008 Aug;16(4):174-81. doi: 10.1007/s10787-007-0016-7.
The present study was undertaken to investigate the analgesic, anti-inflammatory and hypoglycaemic properties of Securidaca longepedunculata (Fresen.) root-bark aqueous extract (SLE) in mice and rats. The analgesic effect of SLE was evaluated by 'hot-plate' and 'acetic acid' analgesic test methods in mice; while its anti-inflammatory and hypoglycaemic effects were examined in rats, using fresh egg albumin-induced pedal oedema, and streptozotocin (STZ)-induced diabetes mellitus models. Morphine (MPN, 10 mg/kg), diclofenac (DIC, 100 mg/kg) and chlorpropamide (250 mg/kg) were used as reference drugs for comparison. SLE (50-800 mg/kg i. p.) produced dose-dependent, significant (p < 0.05-0.001) analgesic effects against thermally- and chemically-induced nociceptive pain in mice. The plant's extract (SLE, 50-800 mg/kg p. o.) also dose-dependently and significantly inhibited (p < 0.05-0.001) fresh egg albumin-induced acute inflammation, and caused significant hypoglycaemia (p < 0.05-0.001) in normal (normoglycaemic) and STZ-treated diabetic (hyperglycaemic) rats. The results of this experimental animal study indicate that S. longepedunculata root-bark aqueous extract (SLE) possesses analgesic, anti-inflammatory and hypoglycaemic properties. These findings lend pharmacological credence to the anecdotal, folkloric and ethnomedical uses of S. longepedunculata root-bark in the treatment, management and/or control of painful, arthritic, inflammatory conditions, as well as in the management and/or control of type 2 diabetes mellitus in some rural communities of South Africa.
本研究旨在探讨长柄隔距兰（Fresen.）根皮水提取物（SLE）对小鼠和大鼠的镇痛、抗炎及降血糖特性。通过“热板”和“醋酸”镇痛试验方法评估SLE对小鼠的镇痛作用；同时，利用新鲜蛋清诱导的足肿胀和链脲佐菌素（STZ）诱导的糖尿病模型，在大鼠中检测其抗炎和降血糖作用。吗啡（MPN，10 mg/kg）、双氯芬酸（DIC，100 mg/kg）和氯磺丙脲（250 mg/kg）用作对照参考药物。SLE（50 - 800 mg/kg腹腔注射）对小鼠热诱导和化学诱导的伤害性疼痛产生剂量依赖性的显著（p < 0.05 - 0.001）镇痛作用。该植物提取物（SLE，50 - 800 mg/kg口服）也剂量依赖性地显著抑制（p < 0.05 - 0.001）新鲜蛋清诱导的急性炎症，并在正常（血糖正常）和STZ处理的糖尿病（高血糖）大鼠中引起显著的低血糖（p < 0.05 - 0.001）。这项实验动物研究结果表明，长柄隔距兰根皮水提取物（SLE）具有镇痛、抗炎和降血糖特性。这些发现为长柄隔距兰根皮在南非一些农村社区用于治疗、管理和/或控制疼痛、关节炎、炎症性疾病以及2型糖尿病的传闻、民间传说和民族医学用途提供了药理学依据。
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