Prieto Esther Alonso, Barnikol Utako B, Soler Ernesto Palmero, Dolan Kevin, Hesselmann Guido, Mohlberg Hartmut, Amunts Katrin, Zilles Karl, Niedeggen Michael, Tass Peter A
Department of Medicine, INB, Research Center Jülich, Germany.
Neuroimage. 2007 Oct 1;37(4):1384-95. doi: 10.1016/j.neuroimage.2007.03.080. Epub 2007 Jun 7.
In order to study the temporal activation course of visual areas V1 and V5 in response to a motion stimulus, a random dots kinematogram paradigm was applied to eight subjects while magnetic fields were recorded using magnetoencephalography (MEG). Sources generating the registered magnetic fields were localized with Magnetic Field Tomography (MFT). Anatomical identification of cytoarchitectonically defined areas V1/V2 and V5 was achieved by means of probabilistic cytoarchitectonic maps. We found that the areas V1/V2 and V5+ (V5 and other adjacent motion sensitive areas) exhibited two main activations peaks at 100-130 ms and at 140-200 ms after motion onset. The first peak found for V1/V2, which corresponds to the visual evoked field (VEF) M1, always preceded the peak found in V5+. Additionally, the V5+ peak was correlated significantly and positively with the second V1/V2 peak. This result supports the idea that the M1 component is generated not only by the visual area V1/V2 (as it is usually proposed), but also by V5+. It reflects a forward connection between both structures, and a feedback projection to V1/V2, which provokes a second activation in V1/V2 around 200 ms. This second V1/V2 activation (corresponding to motion VEF M2) appeared earlier than the second V5+ activation but both peaked simultaneously. This result supports the hypothesis that both areas also generate the M2 component, which reflects a feedback input from V5+ to V1/V2 and a crosstalk between both structures. Our study indicates that during visual motion analysis, V1/V2 and V5+ are activated repeatedly through forward and feedback connections and both contribute to m-VEFs M1 and M2.
为了研究视觉区域V1和V5对运动刺激的时间激活过程，在对八名受试者应用随机点运动图范式的同时，使用脑磁图（MEG）记录磁场。利用磁场断层扫描（MFT）对产生记录磁场的源进行定位。通过概率性细胞构筑图实现对细胞构筑学定义的区域V1/V2和V5的解剖学识别。我们发现，V1/V2区域和V5+区域（V5及其他相邻的运动敏感区域）在运动开始后100 - 130毫秒和140 - 200毫秒出现两个主要激活峰值。在V1/V2区域发现的第一个峰值，对应于视觉诱发电场（VEF）M1，总是先于在V5+区域发现的峰值。此外，V5+区域的峰值与V1/V2区域的第二个峰值显著正相关。这一结果支持了这样一种观点，即M1成分不仅由视觉区域V1/V2产生（如通常所认为的那样），也由V5+区域产生。它反映了这两个结构之间的前向连接以及对V1/V2的反馈投射，这在大约200毫秒时在V1/V2区域引发了第二次激活。V1/V2区域的第二次激活（对应于运动VEF M2）比V5+区域的第二次激活出现得更早，但两者同时达到峰值。这一结果支持了这样的假设，即这两个区域也产生M2成分，它反映了从V5+区域到V1/V2区域的反馈输入以及这两个结构之间的串扰。我们的研究表明，在视觉运动分析过程中，V1/V2区域和V5+区域通过前向和反馈连接被反复激活，并且两者都对运动视觉诱发电场M1和M2有贡献。
