Pellock John M
Division of Child Neurology, Virginia Commonwealth University, School of Medicine Richmond, VA 23298-0211, USA. jpellock@ hsc.vcu.edu
J Child Neurol. 2007 May;22(5 Suppl):9S-13S. doi: 10.1177/0883073807303064.
Seizure emergencies are potentially life-threatening events that are under-recognized. Status epilepticus is associated with considerable rates of morbidity and mortality. Experts currently believe that any episode of seizure activity lasting 5 minutes or longer should be considered status epilepticus. Treatment should be initiated as early as possible; evidence has shown that once seizures persist for 5 to 10 minutes, they are unlikely to stop on their own in the subsequent few minutes. Prehospital treatment with benzodiazepines has been shown to reduce seizure activity significantly compared with seizures that remain untreated until the patient reaches the emergency department. The consequences of delayed treatment of status epilepticus include a serious risk of subsequent prolonged seizure activity or epileptogenesis, memory deficits, and learning difficulties. The importance of timely intervention in generalized tonic-clonic status epilepticus must be emphasized. Recent research has found that emergency department personnel fail to recognize the condition in children in 34% of cases.
癫痫发作紧急情况是潜在的危及生命的事件,但目前未得到充分认识。癫痫持续状态与相当高的发病率和死亡率相关。专家们目前认为,任何持续5分钟或更长时间的癫痫发作活动都应被视为癫痫持续状态。应尽早开始治疗;有证据表明,一旦癫痫发作持续5至10分钟,在随后的几分钟内它们不太可能自行停止。与直到患者到达急诊科才进行治疗的癫痫发作相比,院前使用苯二氮䓬类药物治疗已被证明能显著降低癫痫发作活动。癫痫持续状态延迟治疗的后果包括随后长时间癫痫发作活动或癫痫发生、记忆缺陷和学习困难的严重风险。必须强调及时干预全身性强直阵挛性癫痫持续状态的重要性。最近的研究发现,在34%的病例中,急诊科人员未能识别儿童的这种情况。