Metcalf Donald
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.
Stem Cells. 2007 Oct;25(10):2390-5. doi: 10.1634/stemcells.2007-0544. Epub 2007 Aug 9.
The term hematopoietic stem cells has at times been used to include a miscellany of precursor cells ranging from multipotential self-generating cells to lineage-restricted progenitors with little capacity for self-generation. It is probable that the stem cells of other tissues also vary widely in their multipotentiality and proliferative capacity. This review questions several dogmas regarding the self-generative capacity of various hematopoietic cells, the single episodic origin of hematopoietic cells, and the irreversible nature of progressive mature cell formation in individual hematopoietic lineages. Disclosure of potential conflicts of interest is found at the end of this article.
造血干细胞这个术语有时被用于涵盖一系列前体细胞，从具有多能自我更新能力的细胞到自我更新能力有限的谱系受限祖细胞。其他组织的干细胞在其多能性和增殖能力方面可能也有很大差异。这篇综述对关于各种造血细胞的自我更新能力、造血细胞的单一阶段性起源以及单个造血谱系中成熟细胞形成的不可逆性等几个教条提出了质疑。潜在利益冲突的披露见本文末尾。
