Rongved P, Lindberg B, Klaveness J
Nycomed AS, R & D Division, Oslo, Norway.
Carbohydr Res. 1991 Jul 30;214(2):325-30. doi: 10.1016/0008-6215(91)80039-p.
Biodegradable particles were produced by the cross-linking of starch with epichlorohydrin. Diethylenetriaminepenta-acetic acid (DTPA) was covalently linked to the particles by using DTPA bisanhydride. The small, gadolinium-labelled particles were 40-260% more efficient in vitro proton relaxation agents than the corresponding unbound chelate gadolinium-DTPA. The relaxation properties were dependent on the metal chelate, the particle size, the metal content, and the degree of substitution (d.s.). For the small gadolinium-DTPA particles, an increased d.s. decreased the rate of degradation by alpha-amylase.
可生物降解颗粒通过淀粉与环氧氯丙烷交联制备而成。二乙烯三胺五乙酸（DTPA）通过使用DTPA双酐与颗粒共价连接。与相应的未结合螯合钆-DTPA相比，小的、钆标记的颗粒作为体外质子弛豫剂的效率要高40-260%。弛豫特性取决于金属螯合物、颗粒大小、金属含量和取代度（d.s.）。对于小的钆-DTPA颗粒，取代度增加会降低α-淀粉酶的降解速率。
