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超低磁场中顺磁性示踪剂的早期经验

Early experience of paramagnetic tracers in ultra low magnetic fields.

作者信息

Paajanen H

机构信息

Department of Diagnostic Radiology, University of Turku, Finland.

出版信息

Acta Radiol Suppl. 1990;374:81-3.

PMID:1966974
Abstract

Preliminary results on small gadolinium chelates, superparamagnetic particles and protein conjugated paramagnetic agents used at ultra low field imaging are reported. Ultra low magnetic field was found to be highly sensitive to ferromagnetic particles and signal intensity was decreased at 0.03 mg/ml. Small gadolinium complexes caused similar shortening of relaxation time T1 as in higher field strengths. The magnitude of T1 relaxivity was 1.4 to 2.0 times higher when Gd-DTPA was conjugated to proteins.

摘要

报告了关于在超低场成像中使用的小钆螯合物、超顺磁性颗粒和蛋白质共轭顺磁性剂的初步结果。发现超低磁场对铁磁性颗粒高度敏感,在0.03毫克/毫升时信号强度降低。小钆络合物导致的弛豫时间T1缩短与在更高场强下相似。当钆二乙三胺五乙酸(Gd-DTPA)与蛋白质共轭时,T1弛豫率的幅度高出1.4至2.0倍。

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