Farooqi I Sadaf, Bullmore Edward, Keogh Julia, Gillard Jonathan, O'Rahilly Stephen, Fletcher Paul C
University Department of Medicine and Department of Clinical Biochemistry, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 2QQ, UK.
Science. 2007 Sep 7;317(5843):1355. doi: 10.1126/science.1144599. Epub 2007 Aug 9.
Studies of the fat-derived hormone leptin have provided key insights into the molecular and neural components of feeding behavior and body weight regulation. An important challenge lies in understanding how the rewarding properties of food interact with, and can override, physiological satiety signals and promote overeating. We used functional magnetic resonance imaging to measure brain responses in two human patients with congenital leptin deficiency who were shown images of food before and after 7 days of leptin replacement therapy. Leptin was found to modulate neural activation in key striatal regions, suggesting that the hormone acts on neural circuits governing food intake to diminish the perception of food reward while enhancing the response to satiety signals generated during food consumption.
对脂肪衍生激素瘦素的研究为进食行为和体重调节的分子及神经成分提供了关键见解。一个重要的挑战在于理解食物的奖赏特性如何与生理饱腹感信号相互作用并能够超越这些信号，从而促进暴饮暴食。我们使用功能磁共振成像来测量两名先天性瘦素缺乏症人类患者的大脑反应，在给予瘦素替代疗法7天前后分别向他们展示食物图像。结果发现，瘦素可调节关键纹状体区域的神经激活，这表明该激素作用于控制食物摄入的神经回路，以减少对食物奖赏的感知，同时增强对进食过程中产生的饱腹感信号的反应。
