Vieira Rodolfo P, Claudino Renata C, Duarte Anna Cecília S, Santos Angela B G, Perini Adenir, Faria Neto Hugo C C, Mauad Thais, Martins Mílton A, Dolhnikoff Marisa, Carvalho Celso R F
Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil.
Am J Respir Crit Care Med. 2007 Nov 1;176(9):871-7. doi: 10.1164/rccm.200610-1567OC. Epub 2007 Aug 9.
Aerobic conditioning improves exercise capacity and decreases symptoms in patients with asthma. However, its benefits in the context of allergic airway inflammation are poorly understood.
To evaluate the effects of two intensities of aerobic exercise on airway inflammation and remodeling in a model of chronic allergic lung inflammation.
Mice were subjected to chronic ovalbumin (OVA) sensitization and to 4 weeks of low (OVA+Low) or moderate (OVA+Mod) exercise training in a treadmill. Airway inflammation and remodeling and expression of helper T-cell type 1 and 2 cytokines were evaluated.
OVA-induced allergic airway inflammation and remodeling were characterized by an increase in collagen (288%), elastic fiber (56%), smooth muscle (380%), and epithelial (402%) contents (P < 0.001) when compared with the control group. OVA+Low and OVA+Mod groups presented a decrease in bronchoalveolar lavage fluid eosinophils (respectively, 84 and 75%; P < 0.01) and airway walls (respectively, 94 and 58%; P < 0.001) when compared with the OVA group. OVA+Low and OVA+Mod groups also presented a reduction in the number of peribronchial inflammatory cells expressing IL-4 (respectively, 85 and 75%; P < 0.01) and IL-5 (respectively, 88 and 89%; P < 0.01) when compared with the OVA group. Aerobic conditioning did not change the expression of either IFN-gamma or IL-2 by inflammatory cells or plasma levels of IgE or IgG1. OVA+Low and OVA+Mod groups presented an increase in the expression of IL-10 (P < 0.001). Low and moderate aerobic conditioning also reduced airway remodeling in OVA-sensitized mice when compared with the OVA group.
We concluded that low and moderate aerobic exercise decreases airway inflammation and remodeling in a murine model of asthma.
有氧运动可提高哮喘患者的运动能力并减轻症状。然而，其在过敏性气道炎症背景下的益处尚不清楚。
评估两种强度的有氧运动对慢性过敏性肺部炎症模型中气道炎症和重塑的影响。
将小鼠进行慢性卵清蛋白（OVA）致敏，并在跑步机上进行4周的低强度（OVA+低强度组）或中等强度（OVA+中等强度组）运动训练。评估气道炎症、重塑以及辅助性T细胞1型和2型细胞因子的表达。
与对照组相比，OVA诱导的过敏性气道炎症和重塑表现为胶原蛋白（增加288%）、弹性纤维（增加56%）、平滑肌（增加380%）和上皮细胞（增加402%）含量升高（P<0.001）。与OVA组相比，OVA+低强度组和OVA+中等强度组支气管肺泡灌洗液中的嗜酸性粒细胞分别减少84%和75%（P<0.01），气道壁分别减少94%和58%（P<0.001）。与OVA组相比，OVA+低强度组和OVA+中等强度组中表达IL-4的支气管周围炎症细胞数量分别减少85%和75%（P<0.01），表达IL-5的细胞数量分别减少88%和89%（P<0.01）。有氧运动并未改变炎症细胞中IFN-γ或IL-2的表达，也未改变IgE或IgG1的血浆水平。OVA+低强度组和OVA+中等强度组中IL-10的表达增加（P<0.001）。与OVA组相比，低强度和中等强度的有氧运动也减少了OVA致敏小鼠的气道重塑。
我们得出结论，低强度和中等强度的有氧运动可减轻哮喘小鼠模型中的气道炎症和重塑。
