Teerlink Craig C, Hegewald Matthew J, Cannon-Albright Lisa A
Department of Biomedical Informatics, University of Utah, Salt Lake City, Utah 84112-5750, USA.
Am J Respir Crit Care Med. 2007 Nov 1;176(9):865-70. doi: 10.1164/rccm.200703-448OC. Epub 2007 Aug 9.
Asthma is a multifactorial disease; genetic factors have been suggested but have not been well defined.
This study examined evidence for a heritable component to asthma mortality using a unique data resource consisting of Utah death certificates linked to a genealogy of Utah.
Cases were defined as individuals whose death certificate listed asthma as a cause of death in a registry of all Utah deaths since 1904 (n = 1,553). The genealogical index of familiality analysis was used to compare the average relatedness of asthma deaths to the expected relatedness in the Utah population. Relative risks for asthma death in relatives of individuals who died of asthma are provided for close and distant relatives.
The genealogical index of familiality identified a significantly higher average relatedness in cases (P < 0.001), even when close relationships were ignored. In addition, a significantly increased risk of dying of asthma was observed in first-degree relatives of cases (relative risk = 1.69, P < 0.001) and in second-degree relatives of cases (relative risk = 1.34, P = 0.003).
These results support a heritable contribution to asthma mortality.
哮喘是一种多因素疾病；遗传因素已被提出，但尚未明确界定。
本研究使用一种独特的数据资源，即与犹他州家谱相关联的犹他州死亡证明，来检验哮喘死亡率中遗传成分的证据。
病例定义为在1904年以来犹他州所有死亡登记册中，死亡证明将哮喘列为死因的个体（n = 1553）。家族性分析的家谱指数用于比较哮喘死亡者的平均亲缘关系与犹他州人群的预期亲缘关系。为近亲及远亲提供了死于哮喘个体的亲属中哮喘死亡的相对风险。
家族性分析的家谱指数显示，病例中的平均亲缘关系显著更高（P < 0.001），即使忽略近亲关系也是如此。此外，在病例的一级亲属中观察到死于哮喘的风险显著增加（相对风险 = 1.69，P < 0.001），在病例的二级亲属中也是如此（相对风险 = 1.34，P = 0.003）。
这些结果支持遗传因素对哮喘死亡率有贡献。
