Albright Frederick S, Orlando Patricia, Pavia Andrew T, Jackson George G, Cannon Albright Lisa A
Department of Pharmacotherapy, University of Utah College of Pharmacy, Salt Lake City, USA.
J Infect Dis. 2008 Jan 1;197(1):18-24. doi: 10.1086/524064.
Animal model studies and human epidemiological studies have shown that some infectious diseases develop primarily in individuals with an inherited predisposition. A heritable contribution to the development of severe influenza virus infection (i.e., that which results in death) has not previously been hypothesized or tested. Evidence for a heritable contribution to death due to influenza was examined using a resource consisting of a genealogy of the Utah population linked to death certificates in Utah over a period of 100 years. The relative risks of death due to influenza were estimated for the relatives of 4,855 individuals who died of influenza. Both close and distant relatives of individuals who died of influenza were shown to have a significantly increased risk of dying of influenza, consistent with a combination of shared exposure and genetic effects. These data provide strong support for a heritable contribution to predisposition to death due to influenza.
动物模型研究和人类流行病学研究表明，一些传染病主要在具有遗传易感性的个体中发生。此前尚未有人假设或检验过遗传因素对严重流感病毒感染（即导致死亡的感染）发展的影响。我们利用一个资源来检验遗传因素对流感致死的影响，该资源包含犹他州人群100年间的族谱以及与之关联的死亡证明。我们估算了4855名死于流感的个体的亲属因流感死亡的相对风险。结果显示，死于流感的个体的近亲与远亲患流感死亡的风险均显著增加，这与共同暴露和遗传效应的综合作用相符。这些数据为遗传因素对流感致死易感性的影响提供了有力支持。
