一株来自秘鲁的恶性疟原虫多药耐药菌株对灰绒毛夜猴、南氏夜猴和大声夜猴的适应性研究
Adaptation of a multi-drug resistant strain of Plasmodium falciparum from Peru to Aotus lemurinus griseimembra, A. nancymaae, and A. vociferans monkeys.
作者信息
Collins William E, Sullivan Joann S, Hall Patrice, Ruebush Trenton K, Williams Allison, Grady Katharine K, Bounngaseng Amy, Nace Douglas, Williams Tyrone, Huber Curtis, Galland G Gale, Barnwell John W, Sullivan James J
机构信息
Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention/USPHS/DHHS, 4770 Buford Highway, Chamblee, GA 30341, USA.
出版信息
Am J Trop Med Hyg. 2007 Aug;77(2):261-5.
A strain of Plasmodium falciparum from Peru was adapted to splenectomized Aotus nancymaae and Aotus vociferans monkeys. The Peru 134/CDC strain of P. falciparum was shown to be resistant to treatment with chloroquine in monkeys and partially resistant to mefloquine and malarone. Genetic mutations in crt, dhfr, dhps, and cytochrome b genes conferring drug resistance were also determined for this Peruvian strain of P. falciparum.
一株来自秘鲁的恶性疟原虫适应了脾切除的南希夜猴和大声夜猴。恶性疟原虫的秘鲁134/疾病控制和预防中心菌株在猴子中显示出对氯喹治疗耐药，对甲氟喹和马拉隆部分耐药。还确定了该秘鲁恶性疟原虫菌株中与耐药性相关的crt、dhfr、dhps和细胞色素b基因的基因突变。
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