Shimoda Wataru, Hayashi Mitsuhiro, Murakami Koji, Oyama Tetsunari, Sunagawa Masakatsu
Department of Surgical Oncology, Dokkyo Medical University, Shimotsuge, Tochigi, Japan.
Breast Cancer. 2007;14(3):260-8. doi: 10.2325/jbcs.14.260.
Positron emission tomography (PET) is a non-invasive imaging modality used in the diagnosis and staging of breast cancer. However, several factors can affect fluoro-deoxyglucose (FDG) uptake by a tumor. To clarify the parameters that most affect FDG accumulation in tumors, the relationship between standardized uptake values (SUVs) and clinicopathological factors and immunohistopathological analysis was investigated in breast cancer.
PET studies were performed preoperatively on 37 patients with breast carcinoma. SUVs were counted at one hour (early phase) and at two hours (delayed phase) after FDG injection. The relationships between SUVs and 13 clinical, pathological and immunohistchemical factors were studied.
A significant association was found between FDG accumulation and early and delayed phase mitotic counts (p=0.0018 and 0.0010, respectively), Ki67 positive cell percentage (p=0.0098 and 0.0062, respectively), and nuclear grade (p=0.0232 and 0.0195, respectively). On the other hand, nodal status weakly correlated with the delayed phase (p=0.0907). However, other clinicopathological parameters and immunohistopathological status, which included tumor size, age, histology, estrogen receptor, progesterone receptor and Her2/neu overexpression, did not correlate significantly with FDG uptake.
Mitotic count and Ki67 reflect cellular aggressiveness. These parameters were strongly correlated with tracer uptake. Thus our data suggested that the biological behavior of breast cancer is reflected in the variation of FDG uptake by the tumor. However, whether FDG uptake is a true prognostic and predictive factor remains to be confirmed in larger studies over an extended period of time.
正电子发射断层扫描（PET）是一种用于乳腺癌诊断和分期的非侵入性成像方式。然而，有几个因素会影响肿瘤对氟脱氧葡萄糖（FDG）的摄取。为了阐明最影响肿瘤中FDG积聚的参数，研究了乳腺癌中标准化摄取值（SUV）与临床病理因素及免疫组织病理学分析之间的关系。
对37例乳腺癌患者进行术前PET研究。在注射FDG后1小时（早期）和2小时（延迟期）计算SUV。研究了SUV与13个临床、病理和免疫组化因素之间的关系。
发现FDG积聚与早期和延迟期的有丝分裂计数（分别为p = 0.0018和0.0010）、Ki67阳性细胞百分比（分别为p = 0.0098和0.0062）以及核分级（分别为p = 0.0232和0.0195）之间存在显著关联。另一方面，淋巴结状态与延迟期弱相关（p = 0.0907）。然而，其他临床病理参数和免疫组织病理状态，包括肿瘤大小、年龄、组织学、雌激素受体、孕激素受体和Her2/neu过表达，与FDG摄取无显著相关性。
有丝分裂计数和Ki67反映细胞的侵袭性。这些参数与示踪剂摄取密切相关。因此，我们的数据表明乳腺癌的生物学行为反映在肿瘤对FDG摄取的变化中。然而，FDG摄取是否是一个真正的预后和预测因素仍有待在更长时间的大型研究中得到证实。
