García Vicente A M, Soriano Castrejón A, Relea Calatayud F, Muñoz Madero V, Molina Garrido M J, León Martín A A, Cordero García J M, Pilkington Woll J P, Chacón López-Muñiz I, Palomar Muñoz A
Nuclear Medicine Department, University General Hospital, Ciudad Real, Spain.
Rev Esp Med Nucl Imagen Mol. 2012 Nov-Dec;31(6):308-14. doi: 10.1016/j.remn.2011.12.001. Epub 2012 Mar 19.
To analyse the correlation between (18)F-FDG uptake assessed by PET/CT in locally advanced breast tumours and histopathological and immunohistochemical prognostic factors.
Thirty-six women with breast cancer were prospectively evaluated. PET/CT was requested in the initial staging previous to adjuvant chemotherapy (multicentric study). All the patients underwent an (18)F-FDG PET/CT with a dual-time-point acquisition. Both examinations were evaluated qualitatively and semiquantitatively with calculation of SUVmax values in PET-1 (SUV-1) and in PET-2 (SUV-2) and the percentage variation of the standard uptake values (retention index) between PET-1 and PET-2. Clinical and metabolic stages were assessed according to TNM classification. The biological prognostic parameters, such as the steroid receptor status, p53 and c-erbB-2 expression, proliferation rate (Ki-67), and grading were determined from tissue of the primary tumour. Metabolic and biological parameters were correlated.
A positive relationship was found between semiquantitative metabolic parameters and biological parameters. SUV-1 and SUV-2 values did not show significant statistical correlation (p<.05) except for the clinical tumour size. About the biological parameters, retention index showed the best results with positive and significant relation (p<.05) with estrogen and progesterone receptor status and Ki-67. Isolated SUV values did not show significant relation to these parameters.
Retention index showed the best relation with biological parameters compared to isolated SUVmax values. These data suggest that SUV change over time is a prognostic marker.
分析PET/CT评估的局部晚期乳腺肿瘤中（18）F-FDG摄取与组织病理学和免疫组化预后因素之间的相关性。
对36例乳腺癌女性患者进行前瞻性评估。在辅助化疗前的初始分期时要求进行PET/CT检查（多中心研究）。所有患者均接受了（18）F-FDG PET/CT双时相采集。对两次检查进行定性和半定量评估，计算PET-1（SUV-1）和PET-2（SUV-2）中的SUVmax值以及PET-1和PET-2之间标准摄取值的百分比变化（滞留指数）。根据TNM分类评估临床和代谢分期。从原发性肿瘤组织中确定生物学预后参数，如类固醇受体状态、p53和c-erbB-2表达、增殖率（Ki-67）和分级。对代谢和生物学参数进行相关性分析。
半定量代谢参数与生物学参数之间存在正相关。除临床肿瘤大小外，SUV-1和SUV-2值未显示出显著的统计学相关性（p<0.05）。关于生物学参数，滞留指数显示出最佳结果，与雌激素和孕激素受体状态以及Ki-67呈正相关且具有显著性（p<0.05）。单独的SUV值与这些参数无显著相关性。
与单独的SUVmax值相比，滞留指数与生物学参数的相关性最佳。这些数据表明SUV随时间的变化是一个预后标志物。
