Bang Sung-Jo, Choi Seong Hoon, Park Neung Hwa, Shin Jung Woo, Choy Nari, Kim Suk Hwan, Kim Yangho
Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, South Korea.
J Occup Health. 2007 Jul;49(4):268-72. doi: 10.1539/joh.49.268.
Although high signal intensities in the globus pallidus are frequently observed in T1-weighted magnetic resonance images (MRI) of patients with liver cirrhosis, it is unclear whether these increases are due to portal-systemic shunt or obstruction of biliary excretion. We therefore studied pallidal signals in 18 cancer patients with bile duct obstruction and marked jaundice (>10 mg/dl). Patients who had fever, leukocytosis or liver cirrhosis were excluded to ensure that jaundice was due to bile duct obstruction. All patients showed a dilated intrahepatic duct on computed tomography (CT) scan. A high pallidal signal was observed in one of 18 biliary obstructive patients whereas high signals were highly prevalent in liver cirrhosis. A portal-systemic shunt rather than an obstruction of biliary excretion may be responsible for the increased blood manganese concentrations and pallidal T1 signals in chronic liver diseases.
尽管在肝硬化患者的T1加权磁共振成像（MRI）中经常观察到苍白球高信号强度，但尚不清楚这些信号增强是由于门体分流还是胆汁排泄受阻所致。因此，我们研究了18例患有胆管梗阻和明显黄疸（>10mg/dl）的癌症患者的苍白球信号。排除了发热、白细胞增多或肝硬化的患者，以确保黄疸是由胆管梗阻引起的。所有患者在计算机断层扫描（CT）中均显示肝内胆管扩张。18例胆管梗阻患者中有1例出现苍白球高信号，而在肝硬化患者中高信号非常普遍。门体分流而非胆汁排泄受阻可能是慢性肝病患者血锰浓度升高和苍白球T1信号增强的原因。
