Gajdos M, Spustová V, Stefíková K, Dzúrik R
Centrum klinickej farmakológie Ustavu preventívnej a klinickej medicíny, Bratislava.
Cas Lek Cesk. 1991 Nov 18;130(20-21):598-600.
Organic anions retained in patients with renal failure participate in a substantial way in the metabolic acidosis and thus also the catabolism in renal failure. The basic disorder is the reduced capacity of the transport system of organic ions. Therefore drugs are sought to enhance its activity. Acute investigation of healthy volunteers revealed that 150 mg dipyridamol increased the urinary hippurate excretion, while the serum hippurate concentration declined. In patients with renal failure there is the same tendency, though less marked, and due to the variability of functions of individual patients this trend is insignificant. It is assumed that this hitherto not described action of dipyridamol may be of therapeutic importance when administered to patients with impaired renal function.
肾衰竭患者体内潴留的有机阴离子在很大程度上参与了代谢性酸中毒，进而也参与了肾衰竭时的分解代谢。基本病变是有机离子转运系统功能降低。因此，人们在寻找能增强其活性的药物。对健康志愿者的急性研究表明，150毫克双嘧达莫可增加尿马尿酸盐排泄，而血清马尿酸盐浓度下降。肾衰竭患者也有同样的趋势，尽管不太明显，而且由于个体患者功能的变异性，这种趋势并不显著。据推测，双嘧达莫这种迄今未被描述的作用在应用于肾功能受损患者时可能具有治疗意义。
