Stefíková K, Spustová V, Revúsová V, Polakovicová D, Dzúrik R
Centrum klinickej farmakológie, Ustav preventívnej a klinickej medicíny, Bratislava.
Cas Lek Cesk. 1991 Nov 18;130(20-21):614-5.
The effect of 2.0 g magnesium sulfate on glucose tolerance and immunoreactive insulin (IRI) response to glucose application was studied in 10 healthy normomagnesemic volunteers: a) Serum magnesium concentration (Mg) increased markedly and remained on the increased values during the study. Total erythrocyte Mg concentration did not change. b) The infusion application of 40 g glucose increased glykemia which returned promptly to fasting levels after the infusion termination. Mg did not influence the glycemic response. c) IRI concentration increased even more than glucose to the glucose load. Mg decreased the IRI response and even IRI/glucose ratio significantly. In conclusion, Mg increased insulin sensitivity even in healthy normomagnesemic subjects.
在10名健康的正常血镁志愿者中研究了2.0克硫酸镁对葡萄糖耐量以及对葡萄糖应用的免疫反应性胰岛素（IRI）反应的影响：a）血清镁浓度（Mg）显著升高，并在研究期间保持在升高水平。总红细胞镁浓度未发生变化。b）输注40克葡萄糖会使血糖升高，输注终止后血糖迅速恢复到空腹水平。镁不影响血糖反应。c）IRI浓度对葡萄糖负荷的升高幅度甚至超过葡萄糖。镁显著降低了IRI反应以及IRI/葡萄糖比值。总之，即使在健康的正常血镁受试者中，镁也会增加胰岛素敏感性。
