Ratzmann G W, Ratzmann K P, Meyer L W, Männchen E
Acta Biol Med Ger. 1978;37(3):441-5.
The effect of intravenous application of 1 mg glucagon on serum magnesium concentration, potassium, immunoreactive insulin (IRI), and blood glucose in healthy subjects has been studied. A significant decrease of the serum magnesium concentration was observed beginning 5 min after glucagon injection. There is a tendency of a slight but not statistically significant decrease of potassium level at 60 min. The beginning of the decrease of magnesium level was associated with the maximum of IRI-peak. In contrast to the discussed hypothesis that hyperglycemia and hyperinsulinemia cause a shift for magnesium and potassium from the extracellular into the intracellular space we could demonstrate that hyperglycemia is not a necessary condition for the decreasing effect of glucagon on serum magnesium level.
研究了静脉注射1毫克胰高血糖素对健康受试者血清镁浓度、钾、免疫反应性胰岛素（IRI）和血糖的影响。注射胰高血糖素5分钟后开始观察到血清镁浓度显著下降。60分钟时钾水平有轻微下降趋势，但无统计学意义。镁水平下降的开始与IRI峰值的最大值相关。与高血糖和高胰岛素血症导致镁和钾从细胞外转移到细胞内空间的假设相反，我们可以证明高血糖不是胰高血糖素降低血清镁水平的必要条件。
